Category: Pharmaceutical raw materials and intermediates
Properties: White or white crystalline powder
Loss on drying: ≤ 0.2%
MF: C6H13NO5. HCl
Packaging: 25kg fiber can
1.Overview: Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
2. Structure and metabolism: The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.
3. Clinical use: (1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures. (2) In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia. (3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.
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